Jennifer Lopez in "Hustlers," STX Entertainment, and Diane Lane in "Unfaithful," 20th Century Studios.

When it comes to career choices, Jennifer Lopez has enjoyed blockbuster highs, risky career moves, and occasional regret. On The Howard Stern Show, she revealed one decision that still lingers: turning down the lead in Unfaithful (2002).

The role eventually went to Diane Lane, who earned an Academy Award nomination and critical acclaim. Lopez admitted she dismissed the script at the time, calling it “not good,” but now concedes that director Adian Lyne turned it into something special. “It haunts me a little bit,” she confessed.

Jennifer Lopez and the Missed Opportunity

Kiss of the spider woman, pop viewers.com
(Jennifer Lopez on YouTube, Roadside Attractions)

The story of Unfaithful is a perfect example of how timing and instinct shape Hollywood careers. Jennifer Lopez said she judged the screenplay too harshly and underestimated Lyne’s ability to craft an atmospheric, layered thriller. Lane’s performance as a suburban wife consumed by infidelity won rave reviews and secured an Oscar nomination, turning what could have been a straightforward erotic drama into prestige cinema. Lopez now looks back and wonders what may have been if she had taken the chance.

“I didn’t even know what the hell was going on in my mind at the time,” Lopez admitted to Stern, suggesting that her decision was less strategic and more feeling. That kind of honesty makes her regret more human. It wasn’t a calculation gone wrong, just a moment where instinct didn’t match eventual outcome.

Regret as a Career Reality

Kiss of The Spider Woman, PopViewers.com
(Sundance Film Festival, Roadside Attractions)

It’s easy to assume that stars like Jennifer Lopez only move from one success to another, but regrets are part of the job. Passing on Unfaithful isn’t the only time she’s wondered about what could have been. In other interviews, Lopez has talked about navigating scripts, roles, and expectations in ways that balance her public image with her creative ambitions. Sometimes that means saying yes to films like Hustlers, which earned her some of the best reviews of her career. Other times, it means passing up projects that later turn into award winners.

The truth is, every actor has a list of roles they turned down that went on to make history. For Lopez, the difference is she’s willing to admit when a choice didn’t age well. That openness makes her relatable.

What Jennifer Lopez is Focusing on Now

Despite her regrets, Jennifer Lopez isn’t dwelling on the past. She’s starring in Kiss of the Spider Woman, a project she co-produced, which required her to adopt a striking platinum-blonde look. She confessed the transformation made her nervous but said the risk was worth it. It shows that even after decades in Hollywood, she’s still willing to push boundaries for her art.

Lopez has also been candid about her personal life. In the same Stern interview, she responded to a difficult question about whether she had ever truly been loved. Her answer? “No.” She elaborated by saying that it wasn’t because she’s unlovable, but because some partners “weren’t capable.” That stark vulnerability paired with her career admissions painted a portrait of someone who, despite her success, wrestles with everyday human regrets and doubts.

Looking Back, Looking Ahead

LOS ANGELES, CALIFORNIA – FEBRUARY 08: Jennifer Lopez attends the Los Angeles Special Screening of “Marry Me” on February 08, 2022 in Los Angeles, California. (Photo by Frazer Harrison/Getty Images)

The lesson from the Unfaithful story isn’t that Jennifer Lopez made the wrong choice, but that she recognizes how the decision impacted her career. Lane’s Oscar nod proved the potential she didn’t see, and Lopez is willing to say that out loud. Far from weakening her image, the admissions humanize her.

As she moves into new projects and takes creative control through producing, Lopez is proving past regrets can fuel future risks. Whether or not she lost out on an award-worthy role, she hasn’t lost her drive to surprise herself and devoted audiences. If history is any guide, Jennifer Lopez will keep finding ways to turn missed changes into new opportunities.